effect of vitamin e on blood glucose, lipid profile and blood pressure in type 2 diabetic patients

objective: type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. vitamin e supplementation reduces oxidative stress level in diabetic pa-tients. purpose of this study was to evaluate the effect of vitamin e supplementation on glycemic control and lipid profile in type 2 diabetic patients. material and methods: in this study 31 type 2 diabetic patients with fasting blood sugar (fbs):140-200 mg/dl, triglyceride (tg): 200-400 mg/dl, cholesterol (tc): 200-300 mg/dl and mild hypertension were selected. subjects received vitamin e 800 iu/day for 3 months. at the baseline and end of the study fbs, tc, tg, ldl, hdl, glycated hemoglobin and fasting insulin level were measured. results: in this study 31 type 2 diabetic patients (19 female, 12 male) with mean age 53.03 ± 8.87 years were studied. vitamin e supplementation for 3 months had no positive effect on type 2 diabetic patients. as fbs, tg and fasting insulin decreased but this decline was not significant. also total cholesterol, systolic and diastolic blood pressure changes were not remarkable. conclusion: results of this study showed that 800 iu vitamin e administration for 3 months could not improve blood glucose, lipids , hba1c, fasting insulin, systolic and diastolic bp in type 2 diabetic patients.